Unit Chief

PhD. Alberto Camacho Morales

Phone Number: +52(81) 1340 4370 ext 1757 or 1716

Unit Description

The Neurosciences Unit performs three principal activities: 1) Basic and translational research of the nervous system in the context of metabolic injury associated to diabetes and obesity. 2) Human resource qualification to a bachelor’s degree and Postgraduate level. 3) Consulting and metabolic analysis using animal and cell models.

Particularly, the projects that define this unit’s research areas are aimed to determine neurological mechanisms to regulate corporal energy homeostasis and its impact on behavioral and metabolic injury.  This unit has an interest on identifying molecular mechanism and brain plasticity linked to the energetic control and its disruption as key occurrence in obesity. Furthermore, this unit reaches analysis to identify molecular routes of toxic damage on lipids on the central nervous system during obesity as a determiner for the development of diabetes mellitus type 2. This unit also evaluates the effect of high calorie diet intake on the development of abhorrent behavior on progeny and offspring including the presence of anhedonia, hyperactivity and anxiety. Finally, this unit aims to identify metabolic and tissue injury markers in blood samples on obese individuals with or without diabetes.

To develop the research projects, this unit counts with the intellectual and technological collaboration of national and international researchers including: MD. Maria Fuller, The University of Adelaide, Australia; MD Mario Perello, La Plata, Argentina; MD Luis Concha and MD Fernando Peña, Institute of Neurobiology, UNAM, Mexico; MD Elena Zambrano and MD Armando Tovar of the INCMNSZ, Mexico; MD Héctor Eloy Tamez Pérez and MD Myrthala Juárez Treviño of the Medicine School.

The Neurosciences Unit offers:

  • Writing consultation and submission of research projects to national and international calls.
  • Metabolic analysis service using human and animal cell models (Costs and catalog of services is currently underway).

Relationship programs

  • Institute of Neurobiology, UNAM. Mexico
  • Autonomous University of Querétaro, Mexico.

Research Areas

  • Neuronal metabolic reprogramming during pregnancy and its effect on the generation of obesity in offspring.
  • Neuronal plasticity during high calorie food addiction and its contribution leading to obesity.
  • The role of neuro-inflammation during obesity and its relevance to the development of metabolic injury associated to diabetes.
  • Metabolic injury biomarker identification on obese human blood samples.

Thesis writing

  • All research areas regarding this unit have open opportunities to take part in social service, as a student or volunteer.
  • Axiovert Microscope 40 CFL, ZEISS brand. Inventory: 3927001465.
  • Kitlad Water bath BCK-10 brand Desego.

The remaining laboratory equipment used in analysis is provided thanks to the collaboration with other Units of the Center.

  1. Paipilla AF, Trevino-de Alba C, Cruz-Sanchez JJ, Castro H, Poveda-Espinosa E, Camacho A and Ana Laura de la Garza.* Effect of Dietary Interventions in the Gene Expression Involved in Molecular Mechanisms of Obesity: Evidence-Based Translational Research from Clinical Trials. 2016. ACEPTADO. En prensa.
  2. Vanessa Pérez-Silos, Alberto Camacho, Lizeth Fuentes-Mera. New insights into mesenchymal stem cells subpopulations application for orthopedic regenerative medicine. Stem Cells International. 2016: 3187491.
  3. Robbi Cardenas y Alberto Camacho*. Roles of calcium and Mitochondria-Associated Membranes in the development of obesity and diabetes. Medicina Universitaria. 2016. 18(70): 23-33. *Autor de correspondencia.
  4. Brenda Diaz, Lizeth Fuentes-Mera, Armando Tovar, Teresa Montiel, Lourdes Massieu, Herminia Guadalupe Martínez-Rodríguez and Alberto Camacho*. Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells. Brain Research. 2015. 1627:80-9. *Autor de correspondencia.
  5. Margarita Leyva-Leyva, Annia López-Díaz, Lourdes Barrera, Alberto Camacho-Morales, Felipe Hernandez-Aguilar, Erika M. Carrillo-Casas, Lourdes Arriaga-Pizano, Jaime Calderón-Pérez, Jorge García-Álvarez, Gabriel Orozco-Hoyuela, Cristina Piña-Barba, Augusto Rojas-Martínez, Víktor Romero-Díaz, Jorge Lara-Arias, Nancy Rivera-Morales, César López-Camarillo, Nidia Moncada-Saucedo, Alejandra Galván-De los Santos, Fátima Urzúa-Meza, Luis Villarreal-Gómez y Lizeth Fuentes-Mera. Differential expression of adhesion-related proteins and MAPK pathways leads to suitable osteoblast differentiation of human mesenchymal stem cells subpopulations. Stem Cells and Development. 2015. 24(21):2577-90.
  6. Ilse Delint-Ramirez, Roger Maldonado Ruiz, Ivan Torre-Villalvazo, Lourdes Garza Ocañas, Armando Tovar and Alberto Camacho*. Genetic obesity alters recruitment of TANK-binding kinase 1 and AKT into hypothalamic lipid rafts domains. Neurochemistry International. 2015. 80: 23-32. *Autor de correspondencia.